RESULTS AND FUTURE PROSPECTS OF GDV-GRAPHY APPLICATION IN MEDICAL THERAPY
Alexandrova R.A., Dolinina L.J., Kudrashova E.J., Lubeeva O.A., Magidov M.J., Savitskaya J.S., Philippova N.A.
St.Petersburg State Medical University n.a.I. P.Pavlov, Russia
The principle scientific subject of hospital therapy chair is bronchial asthma (BA). For about three years in the context of new medical technologies’ introduction we have been co-operating with Prof. Konstantin G. Korotkov on Gas Discharge Visualisation method introduction in medical practice.
Our studies are based on cholistic concept of patients’ state valuation, built on synergetics’ conceptions. As synergetics puts it, people are complex nonlinear beings, and they consist of many functional systems, joined by weak and nonlinear links. Any disease is accompanied by changes in functions of many systems with prioritive regulational disturbances in one organ. We have tested 300 BA patients, the majority of them had changes in central and vegetative nervous system and in metabolism, hormonal misbalance symptoms, immunologic displacements. A half of the patients were revealed digestive and renal dysfunction. Dysfunction of digestive system mostly showed itself in dyskinesia, disbacterios, urinary-glomerulus dysfunction. With scintigraphy data they were marked correlation of functional displacement with vegetative misbalance and disturbance of lungs’ perfusion. Thus, apart from chronic inflammation, changed sensitivity and bronchus reactivity, multiple dysfunction of different systems and organs were defined. In order to evaluate such system defects we need cholistic methods of diagnostics which allow evaluating activity disturbances of different functional systems (FS) and organism in general. Cholistic diagnostical methods include studies of biologically active substances, which part in inflammatory cascade of BA patients has been studied well. Such general criterion for ill and healthy person’s state evaluation can be energetic homeokinesis’ indicators.
Up to present time medical practice used methods of recording biopotentials to define functional disturbances of different systems, for example – electrocardiography (ECG) – for heart, electroencephalography (EEG) – for brain.
Is GDV-gram of human’s fingers able to be a marker of energy exchange in inner organs and organism in general? Following physiological concept of European and Oriental medicine we suppose that it is. It is true that reliability of integral functioning of the organism is provided by vast overlap zones of vegetative and somatic innervation. Innervation unity of separate organism’s parts is a structural base for existence of many acupunctural systems – bases for efficient medical impact on all FS of the organism. It has been proved that nearly all organs are projected on hands, distal points of hand fingers have the widest cortex representation.
On the basis of these data we set ourselves the task to study clinical informativity of GDV-graphy.
In the initial stage of the investigation the evaluation of general GDV-gram changes was carried out.
The analysis of work on studies of GDV-graphy clinical informativity for BA patients and healthy people was the following:
1. 40 healthy people had various types of GDV-grams. Mostly K- and R-types were recorded. They were characterised by quite equal radiance corona with complexity of the outer contour – fractality. In R-type fractality was more marked than in K-type. Basic GDV-gram parameters (picture area, noise level, fractal coefficients) for 78 atopic BA patients in mild form of the disease were nearly the same as those for healthy people. We suppose that types of GDV-gram characterise more psychophysiological state of the person than define the nosology.
2. 40 BA patients were checked-up by GDV-graphy, EEG and ECG methods, and the relations between electrophysiological characteristics of hand fingers, brain and heart were revealed. The noise level was higher and GDV-gram fractality was more marked for patients with preserved alpha-activity of cerebrum brain (2nd ECG type). These GDV-gram indicators were much lower for patients with slow delta-waves’ dominance (3rd ECG type). GDV-gram area correlated with ECG RR interval value, the noise level – with ECG PQ interval duration. When the disease gravity increasing, the GDV-gram parameters changed obviously; radiance area, the noise level and picture fractality decreased, EEG marked the decrease of cerebrum brain activity, disturbances in duration of ECG intervals. The revealed for tested patients ECG changes’ nature is typical for vegetative disturbances, and it can be suggested that vegetative nervous system plays a significant part in regulation of energetic homeokinesis of some functional systems and organism on the whole.
3. 20 BA patients were tested their psychological status with Spilberg-Khanin questionnaire and Lusher colour test. The test showed that the dynamics of patients’ psychological states during the course of treatment also correlated with GDV-gram changes. Rise of the patients’ work capacity was accompanied by increase of GDV-gram area. Increase of activity and falling of anxiousity level correlated with increase of GDV-gram noise level. Unity of neurogummoral mechanisms of emotions’ regulation and energetic processes could be based on the fact the same structures of nervous system – limbic and vegetative – participate in their supply.
4. GDV-gram changes analysis f bronchus inflammation nature (eosinophilic or neutrophilic) was carried out for 92 BA patients by the data of sputum cytology and bronchus-alveolar lavage data. More marked GDV-gram changes (broken contours, local outbursts) were noted in the cases with neurophilic inflammation. These differences could be connected with different biochemical base of inflammation variants, for example, with different degree of spareradical oxygenic processes’ activation, specific features of citokines’ profile and disballance of proteolytic and anti-proteolytic functions of lungs. BA exacerbation against the bronchus inflammation process exacerbation background was accompanied by decrease of the radiance area, noise level and picture fractality level. We concluded that GDV-gram dynamic investigation in the course of treatment can help evaluate nature of pathological process’ flow, improvement or failing of the patient’s state.
5. In order to analyse the influence of smoking a cigarette on GDV-gram, 10 healthy people and 10 patients with chronic obstructive disease of lungs were tested. The analysis revealed essential GDV-gram differences in the reaction on smoking a cigarette of chronic bronchitis patients and BA patients. In 5 minutes after smoking a cigarette healthy people and BA patients were noted decrease of GDV-gram area and form coefficient, in 30 minutes – the noise level decreased sharply for BA patients. Chronic bronchitis patients, the opposite, had the increase of GDV-gram area and form coefficient. Positive changes in BEO-grams of chronic bronchitis patients preserved 30 minutes after smoking and were more marked for “chain smokers” (having smoked more than 10 cigarettes a day for more than 5 years). Studies of “smoking” indicator in connection with other state indicators was conducted for 295 BA patients. It revealed statistically essential links of the “smoking” indicator with alveolar macrophags of sputum and bronchoalveolar sample, with neutrophils and changed epithelium of the sample. As literature puts it, smokers’ bronchus inflammation has mostly neurophilic nature, and if eosinophils are revealed, they are characterized by lower functional activity (comparing to BA patients). These might be morpho-functional differences in inflammatory cell markers’ membrane receptors of chronic bronchitis and BA patients that determine the specific features of smoking influence on GDV-gram parameters for the patients of these groups.
6. While evaluating of energetic effects of basic medicamentous and nonmedicamentous remedies used in BA treatment, it was revealed that the most positive effect on GDV-gram indicators is exerted by becotid inhalation, acupuncture, blood ultraviolet radiation and constitutional homeopathic remedies. Broncholithiб berotec inhalation is not so often followed by marked positive GDV changes. The received results prove the synergetic data of efficiency of small influences (homeopathy, acupuncture, in particular) in therapy. With the help of these methods sanogenesis recovery can be reached by autoregulation, and it will take less “wastes” of energy on protection from outer influences. It was revealed the inhibiting influence of dexamatazan intravenous infusion on EEG and GDV-gram parameters. Thus, clinic improvement of BA patients’ state after daxametazan infusion can be achieved at organism’s energoexchange disballance expense. These negative energetic effects of system corticosteroids, when taken for a long time, could be the cause of frequent side effects and complications. By the data of oute respera-tory function’s studies, the direct broncholithic effect of weak influences on organism (acupunctural, for example) is much weaker than the one of corticosteroids. The positive effect of weak influential course treatment could be connected with regulation and normalization of energoexchange. The results of conducted studies let us recommend to use allopatic and naturotherapeutic remedies and therapeutic methods in complex in order to rise BA treatment efficiency. The revealed relations between BA patients’ state indicators in the course of treatment can testify the essential part of energetic homeokinesis changes in the improvement of patients’ functional state.
As to the programme of future investigations in the sphere of GDV-graphy, we would like to note that we are going to continue following the principles of GDV-gram correlation with patients’ state clinic indicators. Clinic informativity of pathology zones (sectoral diagnostics) will be studied by the analysis of GDV-grams for the patients with different diseases of heart, lungs, kidneys, alimentary canal, endocrine system. In our projects we have the studies of influence of age, sex, psychological status features, smoking on GDV-gram of healthy people. We are also going to compare various groups of patients – BA and chronic bronchitis patients, BA patients with ulcerative disease of the stomach and with duodenal ulcer, BA patients with hepatobiliary system pathology. We are going to continue our studies of influence of alternative and complex praparations and methods of BA treatment on GDV-gram. GDV physiological mechanisms’ investigation and the received results’ application for diagnostics and control of therapy efficiency can become the subject of wide international scientific co-operation.